Will Cutting Calories Make You Live Longer?

Will Cutting Calories Make You Live Longer?

Will Cutting Calories Make You Live Longer?

More than a decade ago, researchers at the Pennington Biomedical Research Center in Baton Rouge began recruiting young, healthy Louisianans to voluntarily go hungry for two years. In addition to cutting their daily calories by 25 percentage, the dozens who enrolled also agreed to a weekly battery of tests; blood draw, bone scans, swallowing a pill that measures internal body temperature.

All that sticking and scanning and starving was in the name of the Comprehensive Assessment of Long-Term Consequence of Reducing Intake of Energy, or Calerie–the largest human clinical trial ever to look at the effects of calorie restriction on aging. The National Institutes of Health-funded study also included sites at Washington University in St. Louis and Tufts in Boston. But only the Pennington participants had to also spend 24 sedentary hours inside a sealed room that recorded the contents of their every breath.

These are the measures that scientists( and some analyze participants) are willing to go to understand how a spartan diet impacts the aging process. Calorie restriction is one of the least ridiculous strategies in the burgeoning field of longevity science .~ ATAGEND Study going back to the mid-1 930 s have shown over and over that cutting calories by 25 -5 0 percentage lets yeast, worms, mouse, rats, and monkeys live longer, healthier lives, free from age-related illnes. But there’s much less consensus on the mechanisms through which it works.Which is probably why attempts to simulate fasting with medications have so far all failed FDA acceptance .~ ATAGEND Calerie was designed to ask that question in humans and the first randomized control trial to do so. The researchers selected a 25 percentage limited( between 500 and 800 calories) because it seemed humanly feasible and still likely to show an effect, based on previous animal examines. With 10,000 Americans turning 65 every day, the stakes for good science supporting healthy human aging have never been higher. Regrettably, the most recent outcomes don’t exactly clear things up.

In a paper published Thursday in Cell Metabolism ,~ ATAGEND researchers from Pennington reported for the first time on their whole room calorimeter experiments–the sealed metabolic chambers they stuck participants in for 24 hours. Pennington is one of the few places in the world with these hotel-room-sized microenvironments, the most rigorous way to measure how many calories a person burns and where they come from–fat, protein, or carbohydrates.

After a night of fasting, participants entered the calorimeter promptly at 8: 00 am, and until 8: 00 am the following day they weren’t allowed to leave or exert. Researchers delivered snacks through a small, air-locked cupboard. As fresh air circulated into the room, the air flowing out went through a series of analyzers to measure the ratio of carbon dioxide emissions to oxygen. Nitrogen measurings from urine samples help calculate a total picture of each participant’s resting metabolism.

The picture that emerged was that cutting calories, even modestly, lowered people’s metabolism by 10 percentage. Some of that could be attributed to weight loss( on average folks lost 20 pounds over two years ). But according to the study’s writers, the majority of the change had more to do with altered biological processes, which they find through other biomarkers like insulin and thyroid hormones. “Restricting calories can slow your basal metabolic rate–the energy you need to sustain all normal daily functions, ” says endocrinologist and lead writer Leanne Redman. When the body utilizes less oxygen to generate all its required energy, it produces fewer byproducts of metabolism, things like free radicals that can injury Dna and other cellular machinery. “After two years, the lower rate of metabolism and level of calorie regulation was linked to a reduction in oxidative damage to cells and tissues.”

Now, the study wasn’t long enough to show that calorie limited definitively increased lifespans; That trial would take decades. But Redman contends that this data rejuvenates support for two old but embattled theories of human aging: the slow metabolism’ rate of living’ hypothesi and the oxidative injury theory. The first says that the slower an organism’s metabolism, the longer it will live. The second states that organisms age because cells accumulate free radical damage over time.

Other Calerie researchers don’t buy it. “You can have a low resting metabolic rate because you’re dying of starvation, ” tells Luigi Fontana, an internist who led the Washington University trial. “Does that make it a biomarker of longevity? No. You can be calorie restricted by feeing half a hamburger and a few fries each day but will you live longer? No, you will die of malnutrition.”

Fontana’s own work with Calerie trial data suggests changes to specific insulin pathways matter more than overall metabolism lessening. He also points to studies where rats were made to swim in cold water for hours a day, dropping their metabolism. They didn’t live any longer than room temperature rats. In other studies, scientists overexpressed enzymes that protected mouse from free radicals. They didn’t live any longer either. Redman’s data is interesting, he says, but it’s not the whole picture. “Twenty years ago the dogma was the more calorie restriction the better, ” he says. “What we are finding now is that it’s not the number that are important. Genetics, the composition of the diet, when you feed, what’s in your microbiome, this all influences the impact of calorie restriction.”

But even if analyzing what happens to the human body when you cut calories hasn’t yet explained how cells age, that doesn’t mean it doesn’t have potentially huge health benefits. “Calorie restriction is the only intervention known to delay the onset and progression of cancer, ” says Rafael de Cabo, chief of the National Institute on Aging’s Translational Gerontology Branch. His squad recently completed a 25 -year study of calorie regulation in rhesus monkeys. While they didn’t assure as drastic lifespan improvements as another monkey examine ,~ ATAGEND de Cabo’s team did find lower rates of cancer and metabolic cancers. “If we could get people who work in situations with a lot of environmental pollutants to reduce their calories it would be extremely protective, ” he tells. “But as we very well know , no one is going to be able to withstand eating little longer for their entire life.”

Maybe no one knows that more than Jeffrey Peipert. The 58 -year-old ob-gyn participated in the Washington University trial nine years ago, hoping to bring down his weight, which he’d struggled with his whole life. When he went in, his blood pressure was 132 over 84; after a few months on a restricted calorie regimen it dropped to 115 over 65. A year in he lost 30 pounds. But six months later he ceases. It was just too much work. “It took away my energy, my strength, it definitely took away my sex drive, ” says Peipert. “And tracking calories every day was a total pain in the neck.”

Today he’s gained all the weight back and has to take a pill for hypertension. But at the least he feels like he’s living well, even if he maybe won’t live as long.

Live Long and Prosper

You don’t have to be a post-humanist oracle to profit from the longevity dreams of today’s tech upper-clas. Here’s how Silicon Valley’s Immortalists will help us all remain healthy .~ ATAGEND And no. We don’t mean Peter Thiel’s blood sons. Meet Metformin, the five-cent pill that could give you a few more good years .~ ATAGEND

Want to try calorie cutting without all the numbers and food journaling? Go inside one founder’s personal fast club .~ ATAGEND

Will Cutting Calories Make You Live Longer?
Will Cutting Calories Make You Live Longer?
Will Cutting Calories Make You Live Longer?
Will Cutting Calories Make You Live Longer?
Will Cutting Calories Make You Live Longer?

Will Cutting Calories Make You Live Longer?

Will Cutting Calories Make You Live Longer?

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